Psoriasis and psoriatic arthritis are chronic conditions that can greatly affect a person’s quality of life. Finding the right treatment is important for long-term disease control and relief. A recent study has confirmed that guselkumab is a safe and effective treatment option for these conditions, showing lasting results over 208 weeks (4 years).

What Did the Study Find?

A real-world study published in Clinical and Experimental Dermatology followed 202 patients with psoriasis or psoriatic arthritis who received guselkumab. Researchers analyzed three key aspects of the treatment:

1. Drug Survival (DS) – How long patients continue the treatment.
2. Clinical Effectiveness – Improvement in psoriasis severity using the Psoriasis Area Severity Index (PASI).
3. Safety – Any side effects or adverse reactions.

Significant Improvements in Skin Health

• The average PASI score dropped from 10.88 at the start to just 0.48 after 208 weeks.
• Complete skin clearance (PASI100) was achieved by 30% of patients at week 16, increasing to 64.71% by week 208.
• More patients reached PASI90 (near total skin clearance) and PASI ≤3 (mild disease), proving long-term effectiveness.

High Treatment Adherence and Safety

• 68.5% of patients continued using guselkumab after 4 years, showing high adherence and tolerability.
• Super responders (SRs), patients with remarkable improvement, were less likely to stop treatment.
• No unexpected side effects were reported, highlighting the strong safety profile of guselkumab.

Why This Matters for Patients

This study provides long-term evidence that guselkumab is an excellent choice for managing psoriasis and psoriatic arthritis. With high effectiveness, safety, and sustained results, it offers hope for patients looking for reliable treatment options.

Talk to Your Doctor Today

If you or someone you know is struggling with psoriasis or psoriatic arthritis, talk to a dermatologist or rheumatologist about guselkumab. Long-term disease control is possible, and this treatment could help you achieve clearer skin and a better quality of life.

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